Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors.
about
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells.Blocking EZH2 methylation transferase activity by GSK126 decreases stem cell-like myeloma cells.Inhibitors of Protein Methyltransferases and Demethylases.Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.WD40 repeat domain proteins: a novel target class?Structure, mechanism, and regulation of polycomb repressive complex 2.Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin.Mechanisms of resistance to EZH2 inhibitors in diffuse large B-cell lymphomas.Frequent epigenetic alterations in polycomb repressive complex 2 in osteosarcoma cell lines.An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.
P2860
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P2860
Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Acquisition of a single EZH2 D ...... e to EZH2-targeted inhibitors.
@en
type
label
Acquisition of a single EZH2 D ...... e to EZH2-targeted inhibitors.
@en
prefLabel
Acquisition of a single EZH2 D ...... e to EZH2-targeted inhibitors.
@en
P2093
P2860
P356
P1433
P1476
Acquisition of a single EZH2 D ...... e to EZH2-targeted inhibitors.
@en
P2093
Andrew Garner
Boyang Zhao
Francois Gonzalvez
Justin Pritchard
Sujata Nerle
Theresa Baker
Victor M Rivera
P2860
P304
32646-32655
P356
10.18632/ONCOTARGET.5066
P407
P577
2015-09-02T00:00:00Z