Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
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Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutationsHereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanismChymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YHereditary pancreatitis: current perspectivesCaldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and functionFramework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitisLong-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme ActivationChymotrypsin C mutations in chronic pancreatitis.Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptorsGenetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitisChymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.Genetic and phenotypic heterogeneity in tropical calcific pancreatitisIntragenic duplication: a novel mutational mechanism in hereditary pancreatitisGene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis.Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.Chymotrypsin C (caldecrin) is associated with enamel developmentMesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin CCTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis.Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisFunctional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic PancreatitisA common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death.Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.Proteomic analysis of zymogen granules.Genetics of pancreatitis: a guide for clinicians.Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity.Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.Human cationic trypsinogen is sulfated on Tyr154.Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation.Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.
P2860
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P2860
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
@en
type
label
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
@en
prefLabel
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
@en
P2860
P356
P1476
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.
@en
P2860
P304
11879-11886
P356
10.1074/JBC.M600124200
P407
P577
2006-02-27T00:00:00Z