Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.
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6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesityPhysiological adaptations to low-volume, high-intensity interval training in health and diseaseEpinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat dietNuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscleAMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal musclePGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.Adipogenic and energy metabolism gene networks in longissimus lumborum during rapid post-weaning growth in Angus and Angus x Simmental cattle fed high-starch or low-starch diets.A genome scan for positive selection in thoroughbred horses.Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF ratsMitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.Fiber type conversion by PGC-1α activates lysosomal and autophagosomal biogenesis in both unaffected and Pompe skeletal muscle.The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.Pathogenesis of insulin resistance in skeletal muscle.Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individualsPerinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring.Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1.Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.Potential therapeutic benefits of strategies directed to mitochondria.PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells.Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergeticsA shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys.Fiber type effects on contraction-stimulated glucose uptake and GLUT4 abundance in single fibers from rat skeletal muscleTherapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells.The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acidsEffects of Nitric Oxide Synthase Inhibition on Fiber-Type Composition, Mitochondrial Biogenesis, and SIRT1 Expression in Rat Skeletal MuscleThe role of mitochondria in the pathogenesis of type 2 diabetesIn vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation.Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association studyModified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance.PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscleParadoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile.FAT/CD36 expression is not ablated in spontaneously hypertensive rats.Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle
P2860
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P2860
Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Modest PGC-1alpha overexpressi ...... termyofibrillar, mitochondria.
@en
type
label
Modest PGC-1alpha overexpressi ...... termyofibrillar, mitochondria.
@en
prefLabel
Modest PGC-1alpha overexpressi ...... termyofibrillar, mitochondria.
@en
P2093
P921
P356
P1476
Modest PGC-1alpha overexpressi ...... termyofibrillar, mitochondria.
@en
P2093
Arend Bonen
Carley R Benton
Graham P Holloway
James G Nickerson
James Lally
Jan F C Glatz
John J Heikkila
Joost J F P Luiken
Terry E Graham
Xiao-Xia Han
P304
P356
10.1074/JBC.M704332200
P407
P577
2007-12-12T00:00:00Z