about
Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide.Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug designChemokine cooperativity is caused by competitive glycosaminoglycan binding.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.Examining weak protein-protein interactions in start codon recognition via NMR spectroscopy.New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach.Sulfotyrosine recognition as marker for druggable sites in the extracellular space.Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins.Biased antagonism of CXCR4 avoids antagonist toleranceBicelle size modulates the rate of bacteriorhodopsin folding
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Joshua J Ziarek
@ast
Joshua J Ziarek
@en
Joshua J Ziarek
@es
Joshua J Ziarek
@nl
Joshua J Ziarek
@sl
type
label
Joshua J Ziarek
@ast
Joshua J Ziarek
@en
Joshua J Ziarek
@es
Joshua J Ziarek
@nl
Joshua J Ziarek
@sl
prefLabel
Joshua J Ziarek
@ast
Joshua J Ziarek
@en
Joshua J Ziarek
@es
Joshua J Ziarek
@nl
Joshua J Ziarek
@sl
P106
P21
P31
P496
0000-0002-3740-9999