The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
about
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignmentVersatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine AdductsThe N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesionsMutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerasesWhat a difference a decade makes: insights into translesion DNA synthesis.Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance.DNA adduct structure-function relationships: comparing solution with polymerase structures.Lesion processing: high-fidelity versus lesion-bypass DNA polymerasesVariants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase I and Sulfolobus solfataricus DNA Polymerase IV.Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.
P2860
Q27648053-1589FB09-936D-495D-803F-FF359AA361FEQ27653071-87C17DAA-77CA-4416-BC22-F907DADA002DQ28756561-707B1527-2088-4257-8E62-6918BFCED3E8Q33248846-37ED9B25-8889-4D2F-AB8C-B0E6F588C2F5Q34087170-3344BF4C-A4A2-4E53-904E-7D7E640116E5Q35148064-7E84ED7C-ECC5-4C99-951F-4932BCEE8CC3Q36023692-AC3DF31E-6C7A-4E9E-B572-2BF94609A8B7Q36314384-AFC72550-16F1-4771-9AD0-96A28D48386AQ37021190-5E0EF401-C8D4-43DF-9038-86D23F4E0862Q37136907-E3D21AF6-59FA-4BD7-9586-DBC0341C753AQ37571499-2C29034D-F1B7-4857-B018-6369399C5626Q38731525-3650A682-0FD9-4500-ABA4-188137C53FDDQ41465668-59B8061D-C9E3-4BC4-BFC1-8912EC54BA1AQ41812715-8CB3DB17-7931-43BB-A2F3-292CD27F40B0Q42943436-CDCA62FB-A87C-4A43-BD58-31DAD611C03BQ43021499-C8C2D789-6D79-42B9-9390-9E237802FF29Q45153419-3CBFA4CA-382F-46DA-A1EC-2F11048F38D8Q48284762-2E36E95A-E775-4D0B-8EA7-BE0FEAD02508Q51679163-2EA68558-4B7C-46B8-B2C1-D81D42A5265D
P2860
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The spacious active site of a ...... and computational approaches.
@en
type
label
The spacious active site of a ...... and computational approaches.
@en
prefLabel
The spacious active site of a ...... and computational approaches.
@en
P2093
P2860
P356
P1476
The spacious active site of a ...... and computational approaches.
@en
P2093
David A Scicchitano
Ilya Likhterov
Nicholas E Geacintov
Rebecca A Perlow-Poehnelt
Suse Broyde
P2860
P304
36951-36961
P356
10.1074/JBC.M404332200
P407
P577
2004-06-21T00:00:00Z