All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase. - sprookjes - yvandenbroek - TriplyDB

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

http://www.wikidata.org/entity/Q38617799

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The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus.Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies.Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension FAM122A, a new endogenous inhibitor of protein phosphatase 2A Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function.Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes.A SMAP in the face for cancer.Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.PP2A as a master regulator of the cell cycle.PP2A-B56γ is required for an efficient spindle assembly checkpoint.Modulation of VEGF receptor 2 signaling by protein phosphatases.Miklós Bodanszky Award Lecture: Advances in the selective targeting of protein phosphatase-1 and phosphatase-2A with peptides.The Neurospora crassa PP2A Regulatory Subunits RGB1 and B56 Are Required for Proper Growth and Development and Interact with the NDR Kinase COT1.A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization.Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma.The FEBS Journal in 2018 - putting a bit of color in your life, and your figures.Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition.PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.Distinct B subunits of PP2A regulate the NF-κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA.Therapeutic Targeting of PP2A.Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.A comprehensive in silico analysis of huntingtin and its interactome.Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease.Identification and characterization of novel enhanced cell penetrating peptides for anti-cancer cargo delivery.miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer.RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers.Neuroprotective Effect of Protein Phosphatase 2A/Tristetraprolin Following Subarachnoid Hemorrhage in Rats.Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells.Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis.The impact of phosphatases on proliferative and survival signaling in cancer.

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

http://www.wikidata.org/entity/Q38617799

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年學術文章

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

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Caroline C Farrington

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David B Kastrinsky

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Jaya Sangodkar

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Kimberly McClinch

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Matthew D Galsky

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P2860

CIP2A expression is increased in prostate cancer

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer

The tumor suppressor PP2A Abeta regulates the RalA GTPase

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

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10.1111/FEBS.13573

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6

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283

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26507691

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4803620

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