Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner - sprookjes - yvandenbroek - TriplyDB

Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner

Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner

http://www.wikidata.org/entity/Q38676686

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Molecular regulation of NKCC2 in the thick ascending limb Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis Thick ascending limb of the loop of Henle.Uromodulin in kidney injury: an instigator, bystander, or protector?Genome-wide association studies and contribution to cardiovascular physiology Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.Na+-K+-2Cl- cotransporter type 2 trafficking and activity: the role of interacting proteins.Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock-induced acute kidney injury.Uromodulin: old friend with new roles in health and disease.The signaling pathway of uromodulin and its role in kidney diseases.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).Uromodulin: from monogenic to multifactorial diseases.The hidden hand of chloride in hypertension.Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics.Vasopressin regulation of sodium transport in the distal nephron and collecting duct.Uromodulin: from physiology to rare and complex kidney disorders.Physiological role of SLC12 family members in the kidney.The role of tumor necrosis factor alpha in regulating the expression of Tamm-Horsfall Protein (uromodulin) in thick ascending limbs during kidney injury.Autosomal Dominant Tubulointerstitial Kidney Disease.Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure.Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study.Regulation of renal Na-(K)-Cl cotransporters by vasopressin.The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography.Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.Paradoxical response to furosemide in uromodulin-associated kidney disease.The European Eel NCCβ Gene Encodes a Thiazide-resistant Na-Cl Cotransporter.Tamm Horsfall Glycoprotein and Uromodulin: It Is All about the Tubules!Determination of uromodulin in human urine: influence of storage and processing.A primary culture system of mouse thick ascending limb cells with preserved function and uromodulin processing.Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease.Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia.Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms.

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Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner

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Activation of the bumetanide-s ...... in a chloride-sensitive manner

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Activation of the bumetanide-s ...... in a chloride-sensitive manner

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Carsten Hille

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Gerardo Gamba

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Hajamohideen Raffi

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James Bates

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Kerim Mutig

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Luca Rampoldi

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Maria Castañeda-Bueno

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Michael Godes

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Pontus Persson

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Satish Kumar

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P2860

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice

Ultrastructural localization of Tamm-Horsfall glycoprotein (THP) in rat kidney as revealed by protein A-gold immunocytochemistry

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

Uncompensated polyuria in a mouse model of Bartter's syndrome

Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein.

Two-photon fluorescence lifetime imaging of intracellular chloride in cockroach salivary glands.

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