Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.
about
Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.Global analysis of protein folding using massively parallel design, synthesis, and testing.A thiol probe for measuring unfolded protein load and proteostasis in cells.Hybrid method to solve HP model on 3D lattice and to probe protein stability upon amino acid mutations.Thermophilic adaptation in prokaryotes is constrained by metabolic costs of proteostasis.Thermosensitivity of growth is determined by chaperone-mediated proteome reallocation.Avoidance of toxic misfolding and protein stability do not explain the sequence constraints of highly expressed proteins.Hydrophobicity diversity in globular and nonglobular proteins measured with the Gini index.Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease.Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.Secretome profiling reveals temperature-dependent growth of Aspergillus fumigatus.Mass spectrometry methods to study protein-metabolite interactions.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.Exponentially increased thermal resistance of Salmonella and Enterococcus faecium at reduced water activity.Peptide level turnover measurements enable the study of proteoform dynamics.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Quantifying protein (dis)order.Pervasive Protein Thermal Stability Variation during the Cell Cycle.PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.Large-scale investigation of the reasons why potentially important genes are ignoredMultiscale effects of heating and cooling on genes and gene networksThermal proteome profiling in bacteria: probing protein stateRole of simple descriptors and applicability domain in predicting change in protein thermostabilityBiologically Targeted Magnetic Hyperthermia: Potential and Limitations
P2860
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P2860
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
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2017年學術文章
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name
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.
@en
type
label
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.
@en
prefLabel
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.
@en
P2093
P2860
P50
P356
P1433
P1476
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability
@en
P2093
Manfred Claassen
Stefan Ganscha
Valentina Cappelletti
P2860
P304
P356
10.1126/SCIENCE.AAI7825
P407
P577
2017-02-01T00:00:00Z