Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.
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The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particleN-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencingMultiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiaeSpt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae.The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin stateThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseCompensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interactionDirect screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin.The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Towards a functional understanding of protein N-terminal acetylationContributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair.Symmetry, asymmetry, and kinetics of silencing establishment in Saccharomyces cerevisiae revealed by single-cell optical assaysDot1 and histone H3K79 methylation in natural telomeric and HM silencingThe enigmatic conservation of a Rap1 binding site in the Saccharomyces cerevisiae HMR-E silencer.Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.The establishment of gene silencing at single-cell resolution.Proteomic and genomic characterization of a yeast model for Ogden syndrome.Changes in the genome-wide localization pattern of Sir3 in Saccharomyces cerevisiae during different growth stages.Silent information regulator 3: the Goldilocks of the silencing complex.A modified epigenetics toolbox to study histone modifications on the nucleosome core.The diverse functions of Dot1 and H3K79 methylation.Getting down to the core of histone modifications.Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae.Developmental roles of protein N-terminal acetylation.Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.A common telomeric gene silencing assay is affected by nucleotide metabolism.Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.MeCP2_E1 N-terminal modifications affect its degradation rate and are disrupted by the Ala2Val Rett mutation.Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-terminal acetylase in Saccharomyces cerevisiae.
P2860
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P2860
Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synthetic lethal screens ident ...... nition of the nucleosome core.
@en
Synthetic lethal screens ident ...... nition of the nucleosome core.
@nl
type
label
Synthetic lethal screens ident ...... nition of the nucleosome core.
@en
Synthetic lethal screens ident ...... nition of the nucleosome core.
@nl
prefLabel
Synthetic lethal screens ident ...... nition of the nucleosome core.
@en
Synthetic lethal screens ident ...... nition of the nucleosome core.
@nl
P2093
P2860
P356
P1476
Synthetic lethal screens ident ...... nition of the nucleosome core.
@en
P2093
Alex W Faber
Daniel E Gottschling
David A Egan
Floor Frederiks
Fred van Leeuwen
Kitty F Verzijlbergen
Tibor van Welsem
Zara W Nelson
P2860
P304
P356
10.1128/MCB.02050-07
P407
P577
2008-04-07T00:00:00Z