Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
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Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteinsNatural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivityThe biased nucleotide composition of the HIV genome: a constant factor in a highly variable virusStructural model for deoxycytidine deamination mechanisms of the HIV-1 inactivation enzyme APOBEC3GHIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factorsTurning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)HIV-1 Vif, APOBEC, and intrinsic immunityMultiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allSuppression of APOBEC3-mediated restriction of HIV-1 by VifAPOBEC3 Interference during Replication of Viral GenomesLikely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistanceDifferent mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanismsAPOBEC3G: an intracellular centurionRole of APOBEC3 in genetic diversity among endogenous murine leukemia virusesHypermutation of an ancient human retrovirus by APOBEC3GAID and Apobec3G haphazard deamination and mutational diversityHuman APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.In vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients.Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized miceAPOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon.The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.The inside out of lentiviral vectorsIntensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain.Retroviral restriction factor APOBEC3G delays the initiation of DNA synthesis by HIV-1 reverse transcriptase.Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints.Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.HIV-1 and HIV-2 exhibit similar mutation frequencies and spectra in the absence of G-to-A hypermutation.Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo.Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation.Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality.Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesisBiochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deamination.HIV-1 viral infectivity factor (Vif) alters processive single-stranded DNA scanning of the retroviral restriction factor APOBEC3GComparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants.Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from Kenya.
P2860
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P2860
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
@en
Twin gradients in APOBEC3 edit ...... ics of lentiviral replication.
@nl
type
label
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
@en
Twin gradients in APOBEC3 edit ...... ics of lentiviral replication.
@nl
prefLabel
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
@en
Twin gradients in APOBEC3 edit ...... ics of lentiviral replication.
@nl
P2093
P2860
P356
P1476
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
@en
P2093
Christophe Rusniok
Jean-Pierre Vartanian
Rodolphe Suspène
Simon Wain-Hobson
P2860
P304
P356
10.1093/NAR/GKL555
P407
P577
2006-09-08T00:00:00Z