Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. - sprookjes - yvandenbroek - TriplyDB

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

http://www.wikidata.org/entity/Q39536250

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Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance Clk post-transcriptional control denoises circadian transcription both temporally and spatially.Negative feedback regulation of the ERK1/2 MAPK pathway RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila Computational analyses of synergism in small molecular network motifs Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Models of signalling networks - what cell biologists can gain from them and give to them Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.ODE constrained mixture modelling: a method for unraveling subpopulation structures and dynamics Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.ERK as a model for systems biology of enzyme kinetics in cells.Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops.Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade.Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.Simulated evolution of signal transduction networks.Hierarchic stochastic modelling applied to intracellular Ca(2+) signals Optical control of cell signaling by single-chain photoswitchable kinases A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes.Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype.Branched motifs enable long-range interactions in signaling networks through retrograde propagation A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.Differential Gene Expression in GPR40-Overexpressing Pancreatic β-cells Treated with Linoleic Acid.Hamiltonian Monte Carlo methods for efficient parameter estimation in steady state dynamical systems.Genomic classification of the RAS network identifies a personalized treatment strategy for lung cancer Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines.Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells.Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity Frequency modulation of ERK activation dynamics rewires cell fate.Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging.Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks.Information transfer by leaky, heterogeneous, protein kinase signaling systems.

P2860

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P2860

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

http://www.wikidata.org/entity/Q39536250

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@en

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@nl

type

label

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@en

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@nl

prefLabel

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@en

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

@nl

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Molecular Systems Biology

P1476

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

@en

P2093

Anja Sieber

http://www.w3.org/2001/XMLSchema#string

Christine Sers

http://www.w3.org/2001/XMLSchema#string

Franziska Witzel

http://www.w3.org/2001/XMLSchema#string

Nadine Schmidt

http://www.w3.org/2001/XMLSchema#string

Raphaela Fritsche-Guenther

http://www.w3.org/2001/XMLSchema#string

Sandra Braun

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P2860

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

Regulation and role of Raf-1/B-Raf heterodimerization.

Targeting cancer with small molecule kinase inhibitors

BRAF mutation predicts sensitivity to MEK inhibition

Engineering stability in gene networks by autoregulation

Biological robustness

Robustness in bacterial chemotaxis

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489

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10.1038/MSB.2011.27

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7

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2011-05-01T00:00:00Z

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51166603

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21613978

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3130559

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