Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.
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The HTLV-1 Tax interactomeRetroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKKThe kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growthFoxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathwaysComparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2Role of Tax protein in human T-cell leukemia virus type-I leukemogenicityElevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation.PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell lineRoles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related DiseasesThe need to accessorize: molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycleHuman T-cell leukemia virus type 1 blunts signaling by interferon alphaHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsDiscordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function.Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virusHuman T-cell leukemia virus type 1 expressing nonoverlapping tax and rex genes replicates and immortalizes primary human T lymphocytes but fails to replicate and persist in vivo.Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.A non-SUMOylated tax protein is still functional for NF-κB pathway activation.Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery.HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformationLong-term infection with retroviral structural gene vector provides protection against bovine leukemia virus disease in rabbits.Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisTax and overlapping rex sequences do not confer the distinct transformation tropisms of human T-cell leukemia virus types 1 and 2Clonality of HTLV-2 in natural infection.Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.Move or die: the fate of the Tax oncoprotein of HTLV-1.Ubiquitin-independent proteasomal degradation during oncogenic viral infections.Ras signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cells.Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1.Adult T cell leukemia lymphoma.
P2860
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P2860
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Immortalization of CD4
@nl
Immortalization of CD4(+) and ...... a functional molecular clone.
@en
type
label
Immortalization of CD4
@nl
Immortalization of CD4(+) and ...... a functional molecular clone.
@en
prefLabel
Immortalization of CD4
@nl
Immortalization of CD4(+) and ...... a functional molecular clone.
@en
P2860
P1433
P1476
Immortalization of CD4(+) and ...... a functional molecular clone.
@en
P2093
P2860
P304
P407
P577
1999-06-01T00:00:00Z