Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation
about
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivityHeparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell MigrationSyndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and PrognosticationSyndecans play dual roles as cell adhesion receptors and docking receptorsWhy the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkersTumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomographySyndecan-1 and Its Expanding List of ContactsInsights into the key roles of proteoglycans in breast cancer biology and translational medicineTransmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion.RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCα signaling pathwayMatrix regulators in neural stem cell functions.The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans.Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2.Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate ChainsSyndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesProteoglycans and their roles in brain cancer.Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis.Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins.IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM moleculesHeparanase augments insulin receptor signaling in breast carcinoma.Syndecan and integrin interactomes: large complexes in small spaces.The heparanase/syndecan-1 axis in cancer: mechanisms and therapies.Novel insight into the biological functions of syndecan ectodomain core proteins.Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction.Syndecans as modulators and potential pharmacological targets in cancer progression.Syndecans in angiogenesis and endothelial cell biology.Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth.The role of heparins and nano-heparins as therapeutic tool in breast cancer.Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma.Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.Insulin-like growth factor axis targeting in cancer and tumour angiogenesis - the missing link.Association of insulin receptor and syndecan-1 by insulin with activation of ERK I/II in osteoblast-like UMR-106 cells.Incipient renal transplant dysfunction associates with tubular syndecan-1 expression and shedding.Shed syndecan-2 inhibits angiogenesis
P2860
Q24631177-18F0C5DB-6999-410C-9B58-0EEB3F75EDB3Q26777586-A1AAF929-1C8B-4DE1-90AF-DA56330A2C7CQ26784262-D69B7562-D505-4094-94E2-785B5FE084BAQ27000634-611B8E40-4F0B-4D6D-839E-91ACA962BAFEQ27023385-4D809E45-F273-40AB-8337-C95A81B522DEQ27304350-1E5122CD-8DDA-4D6D-8462-FB2DD7AFE0D0Q28084514-E6D39DED-FFD6-4F74-8019-A868D7569B38Q28085548-C04FF034-1C1D-4FE3-B5D2-2A670B32A9F2Q30525661-C6325048-FD62-4A6F-B841-4A8968B3DA31Q30592498-84DF6E76-395A-4277-80DC-6460386393F3Q33819268-7CDED373-0E5A-431E-AB22-33004963D7E3Q34031745-3C0094D7-F795-444D-AAAB-880A481283DEQ34321430-E76482AB-D8FC-41B0-B23D-C983FFF4D9ABQ35622533-0BC2D43C-71A8-4E85-8062-F906A6A24EC8Q35933767-72747183-2582-4EA3-8846-ADA4CE872188Q36283542-671FC37A-935B-4DC4-99C9-297C353C8DDBQ36436089-1C083403-D9C7-4F05-9438-96E54DCB454AQ36497545-B673742D-5BE1-4AE2-800A-94D951F64400Q36807993-A0D58523-328B-4E7B-84F2-8E8E995B45FAQ36816444-8F41E85C-211F-4DF6-ABD2-E3799EB27F63Q36836804-347C4DE6-2791-4DF0-9EF8-5E1306AD9DF3Q37099808-65CE9810-5AC9-43F3-86F8-4AA4D63DC31AQ37499263-62921849-3332-49E2-B68C-E7C283C2A283Q37581720-83637098-1917-439C-A295-4AC9131D5FE1Q37746011-633152A7-F882-4D33-B33B-A4350033EE4BQ38030208-6F1CAEE7-E342-4DED-9ED9-F970D1E607BDQ38078480-7C2A17AB-54A2-4AFD-A88D-EDC2895CDD99Q38096345-81F49CBD-A94B-430E-B0A3-B9B5FF5B4315Q38122283-EC38B89F-2578-4C0F-B65B-FF09C81881B6Q38189392-E190B979-1EA1-439F-8EBA-47DBABAB2978Q38268462-8D8034B5-1392-49D0-B2B2-D90D448B2335Q38760595-3BCA3B00-22B5-4F7E-8C79-472803994849Q38806104-09D5F3D6-0E52-4045-B667-CBE46C8E735CQ38868904-157E0F5C-EBD8-4623-85DC-3E6AFD332FF0Q38920132-FA7DAF1E-6E5F-4405-B0BC-EE53FB5B8F83Q38985052-9574A72F-F27C-4432-A024-121ADCE944E8Q38990201-3D342983-51B7-49C4-8604-93A565F841F5Q39223814-9076FA14-A1C9-4F0A-B7D5-B8744AD7F347Q40941624-2655DAF2-9FCD-4BB2-82C9-E3EC6E5B33FAQ41984948-55BCBC38-BF46-476F-AE4C-864DAA7D4B57
P2860
Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Syndecan-1 couples the insulin ...... inside-out integrin activation
@en
Syndecan-1 couples the insulin ...... nside-out integrin activation.
@nl
type
label
Syndecan-1 couples the insulin ...... inside-out integrin activation
@en
Syndecan-1 couples the insulin ...... nside-out integrin activation.
@nl
prefLabel
Syndecan-1 couples the insulin ...... inside-out integrin activation
@en
Syndecan-1 couples the insulin ...... nside-out integrin activation.
@nl
P2860
P356
P1476
Syndecan-1 couples the insulin ...... inside-out integrin activation
@en
P2093
Alan C Rapraeger
DeannaLee M Beauvais
P2860
P304
P356
10.1242/JCS.067645
P407
P577
2010-11-01T00:00:00Z