about
The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme.Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion.The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophagesGeneration and propagation of radical reactions on proteins.Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunctionNitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.Hypochlorite-induced oxidation of amino acids, peptides and proteins.EPR spin trapping of protein radicals.Chasing great paths of Helmut Sies "Oxidative Stress".Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndromeRole of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates.β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia.Mammalian heme peroxidases: from molecular mechanisms to health implications.Quantification of protein modification by oxidants.Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space.The role of hypothiocyanous acid (HOSCN) in biological systems.Hypothiocyanous acid: benign or deadly?Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids.Detection and characterisation of radicals in biological materials using EPR methodology.Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells.Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction.Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis.Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells.Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl).The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development.Cellular effects of peptide and protein hydroperoxides.Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins.Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid.CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis.Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum.Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes.Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates.Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation.Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages.The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Clare L Hawkins
@ast
Clare L Hawkins
@en
Clare L Hawkins
@es
Clare L Hawkins
@nl
Clare L Hawkins
@sl
type
label
Clare L Hawkins
@ast
Clare L Hawkins
@en
Clare L Hawkins
@es
Clare L Hawkins
@nl
Clare L Hawkins
@sl
prefLabel
Clare L Hawkins
@ast
Clare L Hawkins
@en
Clare L Hawkins
@es
Clare L Hawkins
@nl
Clare L Hawkins
@sl
P1053
F-6696-2014
P106
P21
P31
P3829
P496
0000-0003-2738-5089