GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
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Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesEndoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cellsTcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell lineChaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpressionJagn1 Is Induced in Response to ER Stress and Regulates Proinsulin BiosynthesisBiosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication.OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.Protein Disulfide Isomerase Superfamily in Disease and the Regulation of ApoptosisOASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migrationGlucose-stimulated translation regulation of insulin by the 5' UTR-binding proteins.IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.Apoptotic events induced by high glucose in human hepatoma HepG2 cells involve endoplasmic reticulum stress and MAPK's activation.Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cellsProinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Novel roles for protein disulphide isomerase in disease states: a double edged sword?Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells.4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts.Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetesModulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.Association between promoter polymorphisms of the GRP78 gene and risk of type 2 diabetes in a Chinese Han populationDisulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetesUpdate on the protective molecular pathways improving pancreatic beta-cell dysfunctionMelatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells.Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.Two phases of disulfide bond formation have differing requirements for oxygen.PERK in beta cell biology and insulin biogenesis.Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1.Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor.p24 family type 1 transmembrane proteins are required for insulin biosynthesis and secretion in pancreatic beta-cells.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.
P2860
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P2860
GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@en
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@nl
type
label
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@en
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@nl
prefLabel
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@en
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@nl
P2093
P2860
P356
P1476
GRP78, but Not Protein-disulfi ...... on in Pancreatic {beta}-Cells.
@en
P2093
Allen Volchuk
Liling Zhang
Tracy Teodoro
P2860
P304
P356
10.1074/JBC.M805477200
P407
P577
2008-12-22T00:00:00Z