Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.
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Quantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stressProtein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding.Mutation of cysteine 46 in IKK-beta increases inflammatory responses.Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
P2860
Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.
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Mutation of nonessential cyste ...... B kinase-β with high affinity.
@en
type
label
Mutation of nonessential cyste ...... B kinase-β with high affinity.
@en
prefLabel
Mutation of nonessential cyste ...... B kinase-β with high affinity.
@en
P2093
P2860
P356
P1433
P1476
Mutation of nonessential cyste ...... κB kinase-β with high affinity
@en
P2093
Adrian Whitty
Kimberley Glover
Mary S Golden
Melanie Herscovitch
Rishitha Bollam
Robert Shaffer
Shaun M Cote
Thomas D Gilmore
Thomas Ennis
P2860
P304
P356
10.1021/BI401368R
P407
P577
2013-12-10T00:00:00Z