Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain. - sprookjes - yvandenbroek - TriplyDB

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

http://www.wikidata.org/entity/Q40419510

about

Structure and functionality in flavivirus NS-proteins: perspectives for drug design Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production Dynamics of Human and Viral RNA Methylation during Zika Virus Infection The flaviviral methyltransferase is a substrate of Casein Kinase 1 Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness.S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.Aptamer Displacement Screen for Flaviviral RNA Methyltransferase Inhibitors.Structure-based identification of functional residues in the nucleoside-2'-O-methylase domain of Bluetongue virus VP4 capping enzyme.Flavivirus RNA cap methyltransferase: structure, function, and inhibition.Sensing of immature particles produced by dengue virus infected cells induces an antiviral response by plasmacytoid dendritic cells.Dengue virus nonstructural protein 5 adopts multiple conformations in solution.Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.Serotype-specific differences in dengue virus non-structural protein 5 nuclear localization Regulation of flavivirus RNA synthesis and capping.Regulation of Flavivirus RNA synthesis and replication Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past.A role for H/ACA and C/D small nucleolar RNAs in viral replication.West Nile virus methyltransferase domain interacts with protein kinase G.Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein.Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase.Development of RNA aptamer that inhibits methyltransferase activity of dengue virus.

P2860

Q23011530-4BC1B99E-5749-4A69-83FE-FE2B43B8584C Q24289239-C914229C-083D-4149-971A-682FE9A20910 Q26700125-6A23C092-AB2F-4FDB-9192-A1419F1BC608 Q26970797-57EBA1C1-6E08-4A1B-A19B-132D49FF5738 Q27316483-C3ABED29-DB17-4ABE-939A-595DB44D9562 Q27468720-B28BDDA5-F61F-4D78-9A04-ACC410D2BB0F Q27486503-D0ACD953-166B-40AE-81D9-45474536EF02 Q27490519-E47CE9CF-1EA8-4386-947B-7938368F965D Q27666321-92263F6B-A711-4523-B971-038274DBC7B5 Q27679917-044D5E15-4229-43DB-AE63-2FF971632ACC Q28548514-ACD8FEC2-DD50-44DD-8568-77B7EA90FC4F Q34070463-115A72EC-984B-4B6E-AB13-BA5EB2D5F06D Q35018619-C5570A48-35A4-45E9-AED8-62662F2EDBDD Q35132417-669F7C62-5078-470E-9CAB-0E280FBCCFB8 Q35162542-142B6F4D-638F-41F7-8936-3271E8F1EB10 Q35178437-0F3337F3-277D-4EAC-8596-AB72ECAA3226 Q35212106-E145C215-18B3-4021-804F-AB5C45B2B486 Q35361219-AACBF821-50CC-4183-B257-C17FC942EBD2 Q36249996-B3D0DFCD-77C4-4D2E-AF00-C718DA0D34FB Q36717946-BA98B54B-6098-4479-9B8F-13CF553091CD Q37311934-A54B40E2-6822-4F06-A544-986DE393F017 Q38127643-B28ECD20-9454-4249-9A8B-4897AAA62DA8 Q38280934-BC61A241-19D1-40E1-8CA4-8F3A59992F4A Q38614539-74631358-6BE4-46B9-AC08-83CF6DC654DE Q39029178-F3B49DB9-AC21-480A-85CA-5363C123F03C Q39122110-BA2094A2-81F0-46E6-8994-15D6F03BA08D Q40185164-5B676093-5846-45F1-ADAD-8649FA1DBFDA Q40398956-E4806E9D-B6B8-4847-BA7A-224457C26C8C Q40525882-35C2DD40-2CFD-4440-9589-3511E571E906 Q45325807-DD6512A4-B679-4CFE-B0B9-4A95446FDC55

P2860

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

http://www.wikidata.org/entity/Q40419510

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

@en

type

label

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

@en

prefLabel

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

@en

P1433

Q40419510-3E7DC316-B5F4-492A-BBB2-A955FE71CA5F

P1476

Q40419510-B4766BE1-4085-45F5-B7A7-E8A689817523

P2093

Q40419510-10BCFEFB-9DC3-447B-9E99-BC86F891457A

Q40419510-48547E62-48AA-4311-B37F-FF30239F4F38

Q40419510-6176D854-5940-423E-9DF4-3F25AE0F710D

Q40419510-63736C91-2D5A-4FBD-BA0C-01754065B7C6

Q40419510-6449191B-7ECC-4CCC-A980-CFF77D0E9474

Q40419510-7657D1D4-A784-4031-A399-1FABCFEA765C

Q40419510-FDEB0094-3D79-461F-A36B-975CDF73889B

Q40419510-FFD85EC9-D33E-4684-A2DA-220916FE36A2

P2860

Q40419510-03B6F7EE-281D-4FA3-BC86-515AAD133696

Q40419510-071290CB-6393-48BD-BB09-ADB55AE7F6D3

Q40419510-08E0864C-F5FC-4E16-9B18-D9F629845C7E

Q40419510-0EC1C9A2-0D47-4502-BECB-0DAD330F5D45

Q40419510-14F4DA24-0AA3-4F98-9EFA-C3B61472CE17

Q40419510-17CDE9E3-A2DC-4DB3-8065-6567D37B721D

Q40419510-17E0007F-DCE5-4443-A154-DDD0D80E3BD0

Q40419510-189A5EC9-084B-4C76-BE55-F02C1BAE165E

Q40419510-197C9EB0-ED98-4707-86BF-01DF8C94BB8C

Q40419510-26D9D6B8-A46B-4796-B4EE-139CEB95065A

P304

Q40419510-98EA4BA7-457E-4494-A494-2D6F801B2106

P31

Q40419510-32208831-F5FE-451D-8446-4D908DF5299E

P356

Q40419510-BB60059B-6245-4C58-8F7D-A93DD88A89F1

P407

Q40419510-FFE434A3-487E-43F9-8F09-60D4C00E09F2

P433

Q40419510-81ED94B5-B1A5-4598-B17C-0D7B66195334

P478

Q40419510-79272965-38ED-42B8-9C7E-22A2AAD273DE

P577

Q40419510-DF321487-99AA-4961-99CE-992889FA9849

P698

Q40419510-799780C3-C6E2-4BCE-923B-0AC81AFE0B39

P921

Q40419510-BA716AB1-5EDE-4E3B-9D61-E42FD6DC69E9

P356

P1433

Journal of Biological Chemistry

P1476

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

@en

P2093

Andrew D Davidson

http://www.w3.org/2001/XMLSchema#string

Helga Kroschewski

http://www.w3.org/2001/XMLSchema#string

Julien Lescar

http://www.w3.org/2001/XMLSchema#string

Peter J Wright

http://www.w3.org/2001/XMLSchema#string

Rebecca E Butcher

http://www.w3.org/2001/XMLSchema#string

Siew Pheng Lim

http://www.w3.org/2001/XMLSchema#string

Subhash G Vasudevan

http://www.w3.org/2001/XMLSchema#string

Thai Leong Yap

http://www.w3.org/2001/XMLSchema#string

P2860

Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly.

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

Structure and Function of Flavivirus NS5 Methyltransferase

Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferase

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

P304

19410-19421

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M800613200

http://www.w3.org/2001/XMLSchema#string

P407

P433

28

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P577

2008-05-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18469001

http://www.w3.org/2001/XMLSchema#string

P921