Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.
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uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.VEGF-initiated angiogenesis and the uPA/uPAR systemuPAR-induced cell adhesion and migration: vitronectin provides the keyUrokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins.In silico docking of urokinase plasminogen activator and integrins.Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells.Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis.The calcineurin-NFAT pathway allows for urokinase receptor-mediated beta3 integrin signaling to cause podocyte injury.Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular diseaseIntegrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathwaySoluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion.Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway.Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.Structural basis of interaction between urokinase-type plasminogen activator and its receptorMMP-9 and uPAR regulated glioma cell migrationVitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophagesPAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrinsRole of urokinase receptor in tumor progression and development.Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins.Participation of the urokinase receptor in neutrophil efferocytosis.Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer.Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.Urokinase plasminogen activator system as a potential target for cancer therapy.Urokinase-controlled tumor penetrating peptide.Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic.Serum suPAR in patients with FSGS: trash or treasure?The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surfaceUrokinase receptor orchestrates the plasminogen system in airway epithelial cell function.The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor.An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor.A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth.Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR.Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR.
P2860
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P2860
Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Domain 2 of the urokinase rece ...... n of a new integrin inhibitor.
@en
type
label
Domain 2 of the urokinase rece ...... n of a new integrin inhibitor.
@en
prefLabel
Domain 2 of the urokinase rece ...... n of a new integrin inhibitor.
@en
P2093
P2860
P356
P1476
Domain 2 of the urokinase rece ...... n of a new integrin inhibitor.
@en
P2093
Bernard Degryse
David J Loskutoff
Francesco Blasi
Massimo Resnati
Ralf-Peter Czekay
P2860
P304
24792-24803
P356
10.1074/JBC.M413954200
P407
P577
2005-04-29T00:00:00Z