Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type
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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsLead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool.Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogsRe-exploration of the mGlu₁ PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR.Emergence of Endocytosis-Dependent mGlu1 LTD at Nucleus Accumbens Synapses After Withdrawal From Cocaine Self-Administration
P2860
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type
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2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
Development of Novel, CNS Pene ...... old, That Potentiate Wild Type
@en
type
label
Development of Novel, CNS Pene ...... old, That Potentiate Wild Type
@en
prefLabel
Development of Novel, CNS Pene ...... old, That Potentiate Wild Type
@en
P2093
P2860
P50
P1476
Development of Novel, CNS Pene ...... old, That Potentiate Wild Type
@en
P2093
Anna L Blobaum
Charles W Locuson
Frank W Byers
Hyekyung P Cho
Jerri M Rook
Pedro M Garcia-Barrantes
Zixiu Xiang
P2860
P304
P356
10.1021/ACS.JMEDCHEM.5B00727
P407
P577
2015-10-01T00:00:00Z