Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.
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Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation TherapyRole of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4RACK1 and CIS mediate the degradation of BimEL in cancer cellsTargeting the Mitotic Catastrophe Signaling Pathway in CancerRegulation of Bim in Health and DiseaseHigh Bak Expression Is Associated with a Favorable Prognosis in Breast Cancer and Sensitizes Breast Cancer Cells to PaclitaxelRapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.Impact of the Bim Deletion Polymorphism on Survival Among Patients With Completely Resected Non-Small-Cell Lung CarcinomaAntagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cellsPaclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cellsRationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach.API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer.Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signalingBim and Bmf in tissue homeostasis and malignant disease.N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation.Inhibition of FOXO1 by small interfering RNA enhances proliferation and inhibits apoptosis of papillary thyroid carcinoma cells via Akt/FOXO1/Bim pathwayAnalysis of BIM (BCL-2 like 11 gene) deletion polymorphism in Chinese non-small cell lung cancer patients.Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment.Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines.Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim.Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatmentA proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomesBH3-only proteins and their effects on cancer.Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology.Organelle-specific initiation of cell death.A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer.Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis.miR-17-5p inhibitor enhances chemosensitivity to gemcitabine via upregulating Bim expression in pancreatic cancer cells.Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.Paclitaxel and TRAIL synergize to kill paclitaxel-resistant small cell lung cancer cells through a caspase-independent mechanism mediated through AIF.BIM induction of apoptosis triggered by EGFR-sensitive and resistance cell lines of non-small-cell lung cancer.Mechanistic insight into taxol-induced cell death.An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.
P2860
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P2860
Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Apoptosis of non-small-cell lu ...... only proapoptotic protein Bim.
@en
type
label
Apoptosis of non-small-cell lu ...... only proapoptotic protein Bim.
@en
prefLabel
Apoptosis of non-small-cell lu ...... only proapoptotic protein Bim.
@en
P2093
P2860
P356
P1476
Apoptosis of non-small-cell lu ...... only proapoptotic protein Bim.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.CDD.4401554
P577
2005-03-01T00:00:00Z
P5875
P6179
1050589146