Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/TxkProtein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsIdentification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomainsA conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cellsProtein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinasesThe Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent mannerThe Tec family kinase Itk exists as a folded monomer in vivo.SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.A novel role for Bruton's tyrosine kinase in hepatocyte growth factor-mediated immunoregulation of dendritic cells.SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITKA unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.Tec family kinases modulate thresholds for thymocyte development and selection.Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha productionMacrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for TecTec family kinases in inflammation and disease.BMX and its role in inflammation, cardiovascular disease, and cancer.Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells.NF-kappaB regulates the transcription of protein tyrosine kinase Tec.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Etk/Bmx activation modulates barrier function in epithelial cells.The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.
P2860
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P2860
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
@en
type
label
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
@en
prefLabel
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
@en
P2093
P2860
P356
P1476
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.
@en
P2093
P2860
P304
13577-13585
P356
10.1074/JBC.274.19.13577
P407
P577
1999-05-01T00:00:00Z