Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope.
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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemiaErythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia.The isolation and characterisation of human monoclonal HLA-A2 antibodies from an immune V gene phage display library.Analysis of human antitopoisomerase-I idiotypesAltered B cell signalling in autoimmunity.The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE.Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation.Human innate B cells: a link between host defense and autoimmunity?Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.Isolated VH4 heavy chain variable regions bind DNA characterization of a recombinant antibody heavy chain library derived from patient(s) with active SLE.Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities.Restricted, canonical, stereotyped and convergent immunoglobulin responses.Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors.Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.B cell superantigens: potential modifiers of the normal human B cell repertoire.Novel diagnostic and therapeutic strategies with genetically engineered human antibodies.Expression of Y7 cross-reactive idiotope on human IgM molecules.Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region.
P2860
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P2860
Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Human monoclonal antibodies ag ...... egion gene-associated epitope.
@en
type
label
Human monoclonal antibodies ag ...... egion gene-associated epitope.
@en
prefLabel
Human monoclonal antibodies ag ...... egion gene-associated epitope.
@en
P2093
P2860
P1476
Human monoclonal antibodies ag ...... egion gene-associated epitope.
@en
P2093
Melamed MD
Sutherland J
Thompson KM
P2860
P304
P356
10.1111/J.1365-3083.1991.TB01574.X
P577
1991-10-01T00:00:00Z