Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials - sprookjes - yvandenbroek - TriplyDB

Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials

Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials

http://www.wikidata.org/entity/Q41868814

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The perils of PCR: can we accurately 'correct' antimalarial trials?Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey?Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia Uncertain outcomes: adjusting for misclassification in antimalarial efficacy studies Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data.Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria.Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility.Differentiating Plasmodium falciparum alleles by transforming Cartesian X,Y data to polar coordinates Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo.Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda.Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure.Multiple-clone infections of Plasmodium vivax: definition of a panel of markers for molecular epidemiology Robust Algorithm for Systematic Classification of Malaria Late Treatment Failures as Recrudescence or Reinfection Using Microsatellite Genotyping.Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso.Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children.Prospective Study of Plasmodium vivax Malaria Recurrence after Radical Treatment with a Chloroquine-Primaquine Standard Regimen in Turbo, Colombia Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies.Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda.Markov chain Monte Carlo and expectation maximization approaches for estimation of haplotype frequencies for multiply infected human blood samples.Serum biochemical parameters and cytokine profiles associated with natural African trypanosome infections in cattle.Genotyping of Plasmodium falciparum using antigenic polymorphic markers and to study anti-malarial drug resistance markers in malaria endemic areas of Bangladesh.Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges.Analysing malaria drug trials on a per-individual or per-clone basis: a comparison of methods.Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape.Four artemisinin-based treatments in African pregnant women with malaria.Comparison of Two Genotyping Methods for Distinguishing Recrudescence from Reinfection in Antimalarial Drug Efficacy/Effectiveness Trials.

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Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials

http://www.wikidata.org/entity/Q41868814

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Impact of transmission intensi ...... n antimalarial clinical trials

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Christian Dokomajilar

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P2860

"Clonal" population structure of the malaria agent Plasmodium falciparum in high-infection regions

Annual Plasmodium falciparum entomological inoculation rates (EIR) across Africa: literature survey, Internet access and review

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.

Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.

Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.

The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005

Molecular epidemiology of malaria.

Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections.

Variation in malaria transmission intensity in seven sites throughout Uganda.

Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.

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3096-3103

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scholarly article

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10.1128/AAC.00159-07

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9

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51

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Bryan Greenhouse

Philip J Rosenthal

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17591848

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2043236

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