Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor.
about
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gammaSrc phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaCholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomersCoarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylationThe ErbB signaling network: receptor heterodimerization in development and cancerPhosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogeneSequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.Studies of ligand-induced site-specific phosphorylation of epidermal growth factor receptor.Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.Sequential multiplex analyte capturing for phosphoprotein profiling.Autophosphorylation: a salient feature of protein kinases.The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor.A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor.Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network.Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor c-terminal tail.Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro.Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.Mutation of proline-1003 to glycine in the epidermal growth factor (EGF) receptor enhances responsiveness to EGF.Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites.Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.Expression of epidermal-growth-factor receptor in the K562 cell line by transfection. Altered receptor biochemistry.Physicochemical characterization of the cytoplasmic domain of the epidermal growth factor receptor and evidence for conformational changes associated with its activation by ammonium sulphate.Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas.The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding.Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.
P2860
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P2860
Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Identification of a novel auto ...... dermal growth factor receptor.
@en
type
label
Identification of a novel auto ...... dermal growth factor receptor.
@en
prefLabel
Identification of a novel auto ...... dermal growth factor receptor.
@en
P2093
P2860
P356
P1433
P1476
Identification of a novel auto ...... dermal growth factor receptor.
@en
P2093
P2860
P304
P356
10.1042/BJ2620659
P407
P577
1989-09-01T00:00:00Z