A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)
about
Tim-3 and its role in regulating anti-tumor immunity.Regulation of T cell responses by the receptor molecule Tim-3.Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells.Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression.The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cellsMeprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating MicrovesiclesTim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.Plasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytes.The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells.ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation.Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.Ca2+ coordination controls sonic hedgehog structure and its Scube2-regulated release.iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.Immune regulation by Tim-3.Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection.Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.Downregulated Tim-3 expression is responsible for the incidence and development of colorectal cancer.Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
P2860
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P2860
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A disintegrin and metalloprote ...... lin and mucin domain 3 (Tim-3)
@en
type
label
A disintegrin and metalloprote ...... lin and mucin domain 3 (Tim-3)
@en
prefLabel
A disintegrin and metalloprote ...... lin and mucin domain 3 (Tim-3)
@en
P2093
P2860
P50
P356
P1476
A disintegrin and metalloprote ...... lin and mucin domain 3 (Tim-3)
@en
P2093
Ahmad Trad
Christin Dewitz
Jürgen Scheller
Katja Möller-Hackbarth
Olga Schweigert
P2860
P304
34529-34544
P356
10.1074/JBC.M113.488478
P407
P577
2013-10-11T00:00:00Z