Role of the RNA polymerase trigger loop in catalysis and pausing.
about
Dissection of Pol II trigger loop function and Pol II activity-dependent control of start site selection in vivoMolecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase.Tagetitoxin inhibits RNA polymerase through trapping of the trigger loopActive site opening and closure control translocation of multisubunit RNA polymeraseBridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residueStructural basis of initial RNA polymerase II transcriptionStructural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry RoutesDivergent contributions of conserved active site residues to transcription by eukaryotic RNA polymerases I and IIRNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription.Trigger loop folding determines transcription rate of Escherichia coli's RNA polymeraseMisincorporation by RNA polymerase is a major source of transcription pausing in vivoStepwise mechanism for transcription fidelityControl of transcriptional fidelity by active center tuning as derived from RNA polymerase endonuclease reactionThe architecture of RNA polymerase fidelityDissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.Translocation and fidelity of Escherichia coli RNA polymeraseColiphage HK022 Nun protein inhibits RNA polymerase translocationAn insertion in the catalytic trigger loop gates the secondary channel of RNA polymerase.Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis.Deletion of switch 3 results in an archaeal RNA polymerase that is defective in transcript elongation.Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movementRNA polymerase II with open and closed trigger loops: active site dynamics and nucleic acid translocationTrigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.Modulation of RNA polymerase activity through the trigger loop foldingA two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase.Five checkpoints maintaining the fidelity of transcription by RNA polymerases in structural and energetic details.The β subunit gate loop is required for RNA polymerase modification by RfaH and NusG.RNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase.E. coli RNA Polymerase Determinants of Open Complex Lifetime and Structure.Transcription initiation factor DksA has diverse effects on RNA chain elongationTrigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis.High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop.Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation.The RNA polymerase bridge helix YFI motif in catalysis, fidelity and translocation.RNA polymerase stalls in a post-translocated register and can hyper-translocate.Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitutionA Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.
P2860
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P2860
Role of the RNA polymerase trigger loop in catalysis and pausing.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Role of the RNA polymerase trigger loop in catalysis and pausing.
@en
Role of the RNA polymerase trigger loop in catalysis and pausing.
@nl
type
label
Role of the RNA polymerase trigger loop in catalysis and pausing.
@en
Role of the RNA polymerase trigger loop in catalysis and pausing.
@nl
prefLabel
Role of the RNA polymerase trigger loop in catalysis and pausing.
@en
Role of the RNA polymerase trigger loop in catalysis and pausing.
@nl
P2860
P356
P1476
Role of the RNA polymerase trigger loop in catalysis and pausing
@en
P2093
Murali Palangat
Robert Landick
P2860
P2888
P304
P356
10.1038/NSMB.1732
P50
P577
2009-12-06T00:00:00Z