Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

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Rational Design of Protein C Activators.PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke.

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Q37704695-0876B4DE-C227-4D4A-930B-1472AB3A4E8A Q47855675-C18E2DDC-8979-4D52-A2BC-264FBAD559E4

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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

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http://www.wikidata.org/entity/Q42261564

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

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2016年論文

@zh-hk

2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

@en

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

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type

Item

label

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

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Limiting prothrombin activatio ...... tly alters hemostasis in mice.

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prefLabel

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

@en

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

@nl

P1476

Limiting prothrombin activatio ...... tly alters hemostasis in mice.

@en

P2093

Charles T Esmon

http://www.w3.org/2001/XMLSchema#string

David R Sweet

http://www.w3.org/2001/XMLSchema#string

Jay L Degen

http://www.w3.org/2001/XMLSchema#string

Joseph S Palumbo

http://www.w3.org/2001/XMLSchema#string

Kathryn E McElhinney

http://www.w3.org/2001/XMLSchema#string

Keith W Kombrinck

http://www.w3.org/2001/XMLSchema#string

Matthew J Flick

http://www.w3.org/2001/XMLSchema#string

Maureen A Shaw

http://www.w3.org/2001/XMLSchema#string

Mei Cheng

http://www.w3.org/2001/XMLSchema#string

Naomi L Esmon

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction

Nucleotide sequence of the gene for human prothrombin

Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke.

Factor XIII activity mediates red blood cell retention in venous thrombi.

Role of thrombin signalling in platelets in haemostasis and thrombosis.

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.

Thrombin drives tumorigenesis in colitis-associated colon cancer

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

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721-731

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scholarly article

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10.1182/BLOOD-2015-11-680280

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English

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128

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Alexander Brill

Denisa D Wagner

Eric S Mullins

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2016-06-01T00:00:00Z

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27252233

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4974202

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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

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P2860

P2860

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

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