Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.
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Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain ExchangedA Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldSupersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope SpikeTargeting host-derived glycans on enveloped viruses for antibody-based vaccine designStructural Constraints Determine the Glycosylation of HIV-1 Envelope TrimersGlycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodiesRecent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1High-throughput profiling of anti-glycan humoral responses to SIV vaccination and challengeHIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual.Glycan microarrays for decoding the glycome.MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans.Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman PrimatesEnvelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycomeAnalysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice.High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection.Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans.Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.Antigenicity and Immunogenicity in HIV-1 Antibody-Based Vaccine Design2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.Toward automated oligosaccharide synthesis.Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragmentsHow to assess the binding strength of antibodies elicited by vaccination against HIV and other viruses.Structural principles controlling HIV envelope glycosylation.Ion Mobility Mass Spectrometry for Ion Recovery and Clean-Up of MS and MS/MS Spectra Obtained from Low Abundance Viral Samples.Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans.The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites.Conference report: "Functional Glycomics in HIV Type 1 Vaccine Design" workshop report, Bethesda, Maryland, April 30-May 1, 2012.Carbohydrate microarrays.STD NMR study of the interactions between antibody 2G12 and synthetic oligomannosides that mimic selected branches of gp120 glycans.Serum glycan-binding IgG antibodies in HIV-1 infection and during the development of broadly neutralizing responses.Antibodies expose multiple weaknesses in the glycan shield of HIV.
P2860
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P2860
Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@en
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@nl
type
label
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@en
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@nl
prefLabel
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@en
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@nl
P2093
P2860
P50
P356
P1433
P1476
Polysaccharide mimicry of the ...... to self oligomannose glycans.
@en
P2093
Angelina S Palma
Camille Bonomelli
Christopher N Scanlan
D Cameron Dunlop
David J Harvey
Fatma Mansab
Raymond A Dwek
Snezana Vasiljevic
P2860
P304
P356
10.1093/GLYCOB/CWQ020
P577
2010-02-24T00:00:00Z