Practical and innate carbon-hydrogen functionalization of heterocycles. - sprookjes - yvandenbroek - TriplyDB

Practical and innate carbon-hydrogen functionalization of heterocycles.

Practical and innate carbon-hydrogen functionalization of heterocycles.

http://www.wikidata.org/entity/Q42403853

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Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method Radicals: Reactive Intermediates with Translational Potential Metal-free C-H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation.Chemo- and site-selective derivatizations of natural products enabling biological studies.Preparation and purification of zinc sulfinate reagents for drug discovery.Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.Selective C-H fluorination of pyridines and diazines inspired by a classic amination reaction.Profound methyl effects in drug discovery and a call for new C-H methylation reactions.Late-stage functionalization of biologically active heterocycles through photoredox catalysis.Academia-industry symbiosis in organic chemistry.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.Palladium-catalyzed intramolecular C-H difluoroalkylation: synthesis of substituted 3,3-difluoro-2-oxindoles.C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.Organic chemistry. Strain-release amination.Copper-Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines.4-Trifluoromethyl-p-quinols as dielectrophiles: three-component, double nucleophilic addition/aromatization reactions.Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes.Introduction of fluorine and fluorine-containing functional groups.Stereoselectively fluorinated N-heterocycles: a brief survey.Sulfinate derivatives: dual and versatile partners in organic synthesis.C-H methylation of heteroarenes inspired by radical SAM methyl transferase.Modern advances in heterocyclic chemistry in drug discovery.Synthesis of imidazo[1,2-a]pyridines: C-H functionalization in the direction of C-S bond formation.Radical cascade cyclization of 1,n-enynes and diynes for the synthesis of carbocycles and heterocycles.Direct synthesis of fluorinated heteroarylether bioisosteres.Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis.Mechanistic Study of a Photocatalyzed C-S Bond Formation Involving Alkyl/Aryl Thiosulfate.Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans.A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.Late-stage deoxyfluorination of alcohols with PhenoFluor.Mild silver-mediated geminal difluorination of styrenes using an air- and moisture-stable fluoroiodane reagent.Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides.A scalable and operationally simple radical trifluoromethylation.Metal-free trifluoromethylation of aromatic and heteroaromatic aldehydes and ketones.Copper-catalyzed direct alkylation of heteroarenes.Radical C-H functionalization of heteroarenes under electrochemical control.Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine Bioconjugation by native chemical tagging of C-H bonds.Meta-selective C-H functionalization using a nitrile-based directing group and cleavable Si-tether.Biocatalytic trifluoromethylation of unprotected phenols.

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P2860

Practical and innate carbon-hydrogen functionalization of heterocycles.

http://www.wikidata.org/entity/Q42403853

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Practical and innate carbon-hydrogen functionalization of heterocycles.

@en

Practical and innate carbon-hydrogen functionalization of heterocycles.

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type

label

Practical and innate carbon-hydrogen functionalization of heterocycles.

@en

Practical and innate carbon-hydrogen functionalization of heterocycles.

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prefLabel

Practical and innate carbon-hydrogen functionalization of heterocycles.

@en

Practical and innate carbon-hydrogen functionalization of heterocycles.

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Practical and innate carbon-hydrogen functionalization of heterocycles.

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Bart Herlé

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Darryl D Dixon

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Erik Daa Funder

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Fionn O'Hara

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Janice A Dixon

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Michael R Collins

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Neal Sach

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Phil S Baran

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Rodrigo A Rodriguez

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Ryan D Baxter

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P2860

A new reagent for direct difluoromethylation

Innate C-H trifluoromethylation of heterocycles

Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides

Fluorine in pharmaceuticals: looking beyond intuition

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Innate and Guided C–H Functionalization Logic

Synopsis of some recent tactical application of bioisosteres in drug design.

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.

Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.

Practical C-H functionalization of quinones with boronic acids.

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10.1038/NATURE11680

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