about
Open for collaboration: an academic platform for drug discovery and development at SciLifeLabBeta2-amino acids in the design of conformationally homogeneous cyclo-peptide scaffolds.Design and synthesis of glycosylated beta3-peptides capable of folding into the 3(14)-helical conformation in water.Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells.On the bridge over the translational valley of death: interview with Per I Arvidsson.Synthesis of novel aryl and heteroaryl acyl sulfonimidamides via Pd-catalyzed carbonylation using a nongaseous precursor.Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.Enantioselective Organocatalyzed Transformations of β-Ketoesters.Sulfonimidamides in Medicinal and Agricultural Chemistry.AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.Synthetic approaches to radiochemical probes for imaging of bacterial infections.Effects of Congo red on aβ(1-40) fibril formation process and morphology.Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors.In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation.Clofazimine protects against mycobacterium tuberculosis dissemination in the CNS following an aerosol challenge in a murine model.The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab.Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach.Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease.Synthesis and NMR elucidation of novel pentacycloundecane-based peptides.Design and study of peptide-based inhibitors of amylin cytotoxicity.Computational, ReactIR-, and NMR-spectroscopic investigations on the chiral formyl anion equivalent N-(alpha-lithiomethylthiomethyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one and related compounds.Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation.Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies.Organocatalyzed stereospecific C-C bond formation of β-lactams.Cyclic beta-tetra- and pentapeptides: synthesis through on-resin cyclization and conformational studies by X-ray, NMR and CD spectroscopy and theoretical calculations.An improved synthesis of Fmoc-N-methyl-alpha-amino acids.Mechanistic insights into the phosphine-free RuCp*-diamine-catalyzed hydrogenation of aryl ketones: experimental and theoretical evidence for an alcohol-mediated dihydrogen activation.The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.Glycosylated foldamers: synthesis of carbohydrate-modified beta3hSer and incorporation into beta-peptides.3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.The outstanding metabolic stability of a 14C-labeled beta-nonapeptide in rats--in vitro and in vivo pharmacokinetic studies.Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors.NOTA: a potent metallo-β-lactamase inhibitor.Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster.A Synthesis of "Dual Warhead" β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams.
P50
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P50
description
Zweeds onderzoeker
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hulumtues
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researcher
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taighdeoir
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հետազոտող
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name
Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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type
label
Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
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Per I Arvidsson
@sq
P1053
N-4864-2013
P106
P21
P27
P31
P3829
P496
0000-0002-9453-6812