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Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologueEpidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processingPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyIdentification of two distinct functions for TGF-beta in early mouse developmentMice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation developmentInactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasisAlk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosusAmnion formation in the mouse embryo: the single amniochorionic fold model.Synaptopodin and 4 novel genes identified in primary sensory neurons.Smad5 is dispensable for adult murine hematopoiesis.Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoEndocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.New intracellular components of bone morphogenetic protein/Smad signaling cascades.BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.Periostin as a biomarker of the amniotic membrane.BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.Smad1/5/8 are myogenic regulators of murine and human mesoangioblastsBMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem CellsThyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assemblyFunctions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survivalZeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelinationFGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components.The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formationTransforming Growth Factor type beta and Smad family signaling in stem cell function.PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.On the origin of amniotic stem cells: of mice and men.Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo.Robustness in angiogenesis: notch and BMP shaping waves.The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways.Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.BMP signaling in vascular biology and dysfunction.Bone Morphogenetic Proteins in Vascular Homeostasis and Disease.Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap.
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An Zwijsen
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P106
P31
P496
0000-0002-8583-1721