about
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocystOrigin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cellsReciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cellsCo-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cellsBifurcation analysis of single-cell gene expression data reveals epigenetic landscapeThe maturing of the human embryonic stem cell transcriptome profile.Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocystIntegrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancerThe unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates.Tumor-derived circulating endothelial cell clusters in colorectal cancer.The importance of study design for detecting differentially abundant features in high-throughput experiments.Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewalBMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.Single-cell mRNA profiling identifies progenitor subclasses in neurospheres.Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endodermHigh throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cellsEset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cellsSingle-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.Single-cell multimodal profiling reveals cellular epigenetic heterogeneity.Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures.Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.Regulation of the murine Nfatc1 gene by NFATc2.Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst.Self-aggregation characteristics of recombinantly expressed human elastin polypeptides.DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy.The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation.Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development.
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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type
label
Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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prefLabel
Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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Paul Robson
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P1153
7101768047
P1960
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P2456
P31
P496
0000-0002-0191-3958