Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.
about
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SETTherapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's diseaseHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseMemantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive ImpairmentI1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2ADownregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice.Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice.Mechanisms of tau-induced neurodegeneration.Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications.Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorialUp-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.Developing pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.Genome-wide copy-number variation study of psychosis in Alzheimer's disease.GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.Novel therapeutic strategies for neurodegenerative disease.Tau and neurodegenerative disease: the story so far.An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.Hyperphosphorylation-induced tau oligomersA novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain.Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer.CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment.
P2860
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P2860
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@en
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@nl
type
label
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@en
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@nl
prefLabel
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@en
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@nl
P2093
P2860
P1433
P1476
Inhibitors of protein phosphat ...... type hyperphosphorylated tau.
@en
P2093
Ichiro Tsujio
Khalid Iqbal
Leszek Kotula
Tanweer Zaidi
P2860
P304
P356
10.1016/J.FEBSLET.2004.11.097
P407
P577
2005-01-01T00:00:00Z