Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
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A genome-wide screen for genetic variants that modify the recruitment of REST to its target genesThe ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationThe coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compoundRegulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytesCluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions.An Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.Sequence-dependent sliding kinetics of p53Regression based predictor for p53 transactivation.Cooperativity dominates the genomic organization of p53-response elements: a mechanistic viewConservation of DNA-binding specificity and oligomerisation properties within the p53 family.Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies.Lysine120 interactions with p53 response elements can allosterically direct p53 organization.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Widespread site-dependent buffering of human regulatory polymorphism.Inappropriate p53 activation during development induces features of CHARGE syndrome.Stability of p53 homologsMolecular basis for modulation of the p53 target selectivity by KLF4.Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.Impact of Alu repeats on the evolution of human p53 binding sites.Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers.p53 binding to human genome: crowd control navigation in chromatin contextP53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.Identification of new p53 target microRNAs by bioinformatics and functional analysisSingle-nucleotide mutation matrix: a new model for predicting the NF-κB DNA binding sites.Evolution of p53 transactivation specificity through the lens of a yeast-based functional assayWhole-genome cartography of p53 response elements ranked on transactivation potential.Distinct p53 genomic binding patterns in normal and cancer-derived human cells.Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.Protein-DNA interactions: structural, thermodynamic and clustering patterns of conserved residues in DNA-binding proteins.An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extractsRedefining the p53 response element.Ultraslow oligomerization equilibria of p53 and its implications.A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest.
P2860
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P2860
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@en
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@nl
type
label
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@en
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@nl
prefLabel
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@en
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@nl
P2860
P356
P1476
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
@en
P2860
P304
P356
10.1093/NAR/GKM1040
P407
P577
2008-01-30T00:00:00Z