about
Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxaIdentification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrixDiscovery and functional analysis of a retinitis pigmentosa gene, C2ORF71Fibulin 5 forms a compact dimer in physiological solutions.Immunolocalisation of opticin in the human eyeLRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineageThe vitreous glycoprotein opticin inhibits preretinal neovascularizationSeven new loci associated with age-related macular degeneration.Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan.Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia.Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesivenessGenetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degenerationTissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Characterization of opticin and evidence of stable dimerization in solution.The role of the posterior ciliary body in the biosynthesis of vitreous humour.Vision impairment and dual sensory problems in middle age.Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract FormationMapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.Focus on molecules: opticin.Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans.Whole Genome Sequencing Increases Molecular Diagnostic Yield Compared with Current Diagnostic Testing for Inherited Retinal Disease.Vitrectomy for primary symptomatic vitreous opacities: an evidence-based review.Introduction to metabolomics and its applications in ophthalmology.Adult vitreous structure and postnatal changes.Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells.Vitreous as a substrate for vitreolysis.Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.Iron, zinc, and copper in retinal physiology and disease.The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments.Opticin binds to heparan and chondroitin sulfate proteoglycans.Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement RegulationAge-related macular degeneration and the role of the complement system.The role of extracellular matrix in retinal vascular development and preretinal neovascularization.Molecular findings from 537 individuals with inherited retinal disease.
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hulumtues
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researcher
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wetenschapper
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հետազոտող
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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Paul Bishop
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P106
P21
P31
P496
0000-0001-7937-7932