about
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors.Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis.Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation.Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways.TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy.The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants.Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.Training the 21st Century Immunologist.The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae.Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity.Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms.The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum AdjuvantsIncreased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance.Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics.Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.Similarities and differences of innate immune responses elicited by smooth and rough LPSIL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditionsTargeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitorEndogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammationStructural and functional analysis of a potent sarbecovirus neutralizing antibody
P50
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P50
description
onderzoeker
@nl
researcher ORCID: 0000-0001-8282-7658
@en
name
Roberto Spreafico
@ast
Roberto Spreafico
@en
Roberto Spreafico
@es
Roberto Spreafico
@nl
Roberto Spreafico
@sl
type
label
Roberto Spreafico
@ast
Roberto Spreafico
@en
Roberto Spreafico
@es
Roberto Spreafico
@nl
Roberto Spreafico
@sl
prefLabel
Roberto Spreafico
@ast
Roberto Spreafico
@en
Roberto Spreafico
@es
Roberto Spreafico
@nl
Roberto Spreafico
@sl
P108
P106
P108
P1153
36751783900
P21
P2798
P31
P496
0000-0001-8282-7658