Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.

about

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase Role of NEK2A in human cancer and its therapeutic potentials.Targeting NEK2 as a promising therapeutic approach for cancer treatment.

P2860

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P2860

Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.

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http://www.wikidata.org/entity/Q44143974

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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name

Model system for irreversible ...... ated substituted heterocycles.

@en

Model system for irreversible ...... ated substituted heterocycles.

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type

Item

label

Model system for irreversible ...... ated substituted heterocycles.

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Model system for irreversible ...... ated substituted heterocycles.

@nl

prefLabel

Model system for irreversible ...... ated substituted heterocycles.

@en

Model system for irreversible ...... ated substituted heterocycles.

@nl

P1476

Model system for irreversible ...... ated substituted heterocycles.

@en

P2093

Benoit Carbain

http://www.w3.org/2001/XMLSchema#string

Bernard T Golding

http://www.w3.org/2001/XMLSchema#string

Carlo M Bawn

http://www.w3.org/2001/XMLSchema#string

Celine Cano

http://www.w3.org/2001/XMLSchema#string

Christopher J Matheson

http://www.w3.org/2001/XMLSchema#string

Christopher R Coxon

http://www.w3.org/2001/XMLSchema#string

David M Turner

http://www.w3.org/2001/XMLSchema#string

Honorine Lebraud

http://www.w3.org/2001/XMLSchema#string

Ian R Hardcastle

http://www.w3.org/2001/XMLSchema#string

Roger J Griffin

http://www.w3.org/2001/XMLSchema#string

P2860

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Developing irreversible inhibitors of the protein kinase cysteinome

Chemical genetic strategy for targeting protein kinases based on covalent complementarity

Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group

Targeting cancer with small molecule kinase inhibitors

Kinetics of binding and diffusivity of leucine-enkephalin in large unilamellar vesicle by pulsed-field-gradient 1H NMR in situ.

Covalent modifiers: an orthogonal approach to drug design.

The resurgence of covalent drugs.

Kinase drug discovery--what's next in the field?

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

P304

141-148

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P31

scholarly article

P356

10.1039/C3OB41806E

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P433

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P478

http://www.w3.org/2001/XMLSchema#string

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Ulrich Baisch

Ross W. Harrington

P577

2013-11-08T00:00:00Z

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P5875

258430638

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P698

24213855

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Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.

about

P2860

P2860

Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698