Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
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Developmental potential for endomorphin opioidmimetic drugsActivity of opioid ligands in cells expressing cloned mu opioid receptorsClinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeysStandard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonistsAllostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesOpioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesicsActivation profiles of opioid ligands in HEK cells expressing delta opioid receptors.Opioid receptor trafficking and interaction in nociceptorsOpioid receptors: toward separation of analgesic from undesirable effectsStructural basis for bifunctional peptide recognition at human δ-opioid receptorHeterodimerization of mu and delta opioid receptors: A role in opiate synergyMu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cellsAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismReceptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimersIdentification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreBi- or multifunctional opioid peptide drugs.Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor.Opioids and Opioid Maintenance Therapies: Their Impact on Monocyte-Mediated HIV Neuropathogenesis.Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene.Opioid-receptor-heteromer-specific trafficking and pharmacology.Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.How to design an opioid drug that causes reduced tolerance and dependence.Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand seriesPharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).Mix and match: heterodimers and opioid tolerance.Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects.Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors.Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.In vivo opioid receptor heteromerization: where do we stand?Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor traffickingSynthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-olsDesign, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligandsImplication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide.
P2860
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P2860
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Selective blockage of delta op ...... erance and dependence in mice.
@en
Selective blockage of delta op ...... erance and dependence in mice.
@nl
type
label
Selective blockage of delta op ...... erance and dependence in mice.
@en
Selective blockage of delta op ...... erance and dependence in mice.
@nl
prefLabel
Selective blockage of delta op ...... erance and dependence in mice.
@en
Selective blockage of delta op ...... erance and dependence in mice.
@nl
P2093
P1476
Selective blockage of delta op ...... lerance and dependence in mice
@en
P2093
A E Takemori
E E Abdelhamid
P S Portoghese
P304
P407
P577
1991-07-01T00:00:00Z