Downregulation of SMAD2/3:SMAD4 transcriptional activity
about
SKI/SKIL binds SMAD complex; suppressing TGF-beta signalingSMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKILUbiquitination of SKI/SKIL by RNF111/SMURF2Degradation of ubiquitinated SKI/SKILTRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleusTRIM33 monoubiquitinates SMAD4Ubiquitinated SMAD4 translocates from the nucleus to the cytosolUSP9X (FAM) binds to ubiquitinated SMAD4USP9X (FAM) deubiquitinates SMAD4NEDD4L binds phosphorylated linker region of SMAD2/3NEDD4L ubiquitinates SMAD2/3Degradation of SMAD2/3:SMAD4 complexSMURF2 binds SMAD3 phosphorylated in the linker regionSMURF2 monoubiquitinates SMAD3TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimerPARP1 binds SMAD2/3:SMAD4 heterotrimerPARP1 ADP-ribosylates SMAD3 and SMAD4PPM1A protein phosphatase binds phosphorylated SMAD2/3PPM1A dephosphorylates nuclear SMAD2/3Dephosphorylated SMAD2/3 translocates to the cytosolUbiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
P361
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P361
Downregulation of SMAD2/3:SMAD4 transcriptional activity
description
An instance of the biological ...... ional activity in Homo sapiens
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name
Downregulation of SMAD2/3:SMAD4 transcriptional activity
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type
label
Downregulation of SMAD2/3:SMAD4 transcriptional activity
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prefLabel
Downregulation of SMAD2/3:SMAD4 transcriptional activity
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P2860
P527
P2860
P3937
R-HSA-2173795