about
Che-1 activates XIAP expression in response to DNA damageChe-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpointIn vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell linesPatient-derived xenografts: a relevant preclinical model for drug developmentEfficacy of a nitric oxide-releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenograftsEffect of small molecules modulating androgen receptor (SARMs) in human prostate cancer modelsTelomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectStabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion.Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivoN-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesRas inhibition amplifies cisplatin sensitivity of human glioblastoma.TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft.The future of antisense therapy: combination with anticancer treatments.Telomerase as a new target for the treatment of hormone-refractory prostate cancer.Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model.N-methylformamide induces changes on adhesive properties and lung-colonizing potential of M14 melanoma cells.Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid.Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceTargeting different signaling pathways with antisense oligonucleotides combination for cancer therapy.NCX 4040, an NO-donating acetylsalicylic acid derivative: efficacy and mechanisms of action in cancer cells.Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsA fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells.Transferrin-Targeted Nanoparticles Containing Zoledronic Acid as a Potential Tool to Inhibit Glioblastoma Growth.Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells.Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer.A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides.Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin.Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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type
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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Carlo Leonetti
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P106
P1153
7004669245
P21
P31
P496
0000-0002-3526-7827