Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
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Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's diseaseNovel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and CognitionBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Drug repositioning approaches for the discovery of new therapeutics for Alzheimer's diseasePhosphodiesterases as therapeutic targets for Alzheimer's disease.Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injuryAmyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability?Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative DiseasesOptical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment.Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloidDesign and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy.Sildenafil enhances neurogenesis and oligodendrogenesis in ischemic brain of middle-aged moused-serine levels in Alzheimer's disease: implications for novel biomarker developmentEnhancing cognition before clinical symptoms of dementia.Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neuronsNeuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage.Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic MiceSildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.Sildenafil improves epicenter vascular perfusion but not hindlimb functional recovery after contusive spinal cord injury in miceMulti-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model.cAMP-Inhibits Cytoplasmic Phospholipase A₂ and Protects Neurons against Amyloid-β-Induced Synapse DamageRodent models for Alzheimer's disease drug discovery.Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat.Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions.A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells.Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic DiseaseDevelopment of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain.Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficitsEndothelial nitric oxide deficiency promotes Alzheimer's disease pathologySupplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice.
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P2860
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@en
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@nl
type
label
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@en
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@nl
prefLabel
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@en
Phosphodiesterase 5 inhibition ...... zheimer's disease mouse model.
@nl
P2093
P50
P1476
Phosphodiesterase 5 inhibition ...... lzheimer's disease mouse model
@en
P2093
Agnieszka Staniszewski
Donald W Landry
Elena Leznik
Hong Zhang
Lucia Privitera
Shi Xian Deng
Shumin Liu
P304
P356
10.1523/JNEUROSCI.0864-09.2009
P407
P577
2009-06-01T00:00:00Z