Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment.
about
Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domainNovel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewHigh throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discoverySH2 modified STAT1 induces HLA-I expression and improves IFN-γ signaling in IFN-α resistant HCV replicon cells.Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.High-throughput screening normalized to biological response: application to antiviral drug discovery.Host epithelial-viral interactions as cause and cure for asthma.Role of PKCdelta in IFN-gamma-inducible CIITA gene expression.A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosisSTAT1 modification improves therapeutic effects of interferons on lung cancer cellsAsthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergensPARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infectionImmunogenetic programs for viral induction of mucous cell metaplasiaThe role of airway epithelial cells and innate immune cells in chronic respiratory disease.Parainfluenza Virus 3 Blocks Antiviral Mediators Downstream of the Interferon Lambda Receptor by Modulating Stat1 PhosphorylationNovel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity.β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling.Elevated activity of STAT3C due to higher DNA binding affinity of phosphotyrosine dimer rather than covalent dimer formation.Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression.Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium.Vascular importance of the miR-212/132 cluster.
P2860
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P2860
Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@en
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@nl
type
label
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@en
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@nl
prefLabel
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@en
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@nl
P2093
P2860
P356
P1476
Modification of the Stat1 SH2 ...... otein coactivator recruitment.
@en
P2093
Guangming Huang
Kazutaka Takami
Mindy S Lo
William T Roswit
Yong Zhang
P2860
P304
34306-34315
P356
10.1074/JBC.M503263200
P407
P577
2005-08-17T00:00:00Z