Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling.
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Syndecans as Cell Surface Receptors in Cancer Biology. A Focus on their Interaction with PDZ Domain ProteinsSyndecan-4 signaling at a glanceSyndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathwayNeuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoAA dynamic view of domain-motif interactions.Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases.Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potentialSyndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrixp190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish.Synergistic control of cell adhesion by integrins and syndecans.Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.Protein kinase C, focal adhesions and the regulation of cell migration.Syndecan and integrin interactomes: large complexes in small spaces.Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour.A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.Syndecans in heart fibrosis.The role of heparan sulphate in development: the ectodermal story.Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation.Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates.Syndecan-4 phosphorylation is a control point for integrin recycling.Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing.The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner.The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.Lysophosphatidylcholine-mediated functional inactivation of syndecan-4 results in decreased adhesion and motility of dendritic cells.
P2860
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P2860
Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling.
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2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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name
Structural basis of syndecan-4 ...... switch to regulate signaling.
@en
Structural basis of syndecan-4 ...... switch to regulate signaling.
@nl
type
label
Structural basis of syndecan-4 ...... switch to regulate signaling.
@en
Structural basis of syndecan-4 ...... switch to regulate signaling.
@nl
prefLabel
Structural basis of syndecan-4 ...... switch to regulate signaling.
@en
Structural basis of syndecan-4 ...... switch to regulate signaling.
@nl
P2093
P1476
Structural basis of syndecan-4 ...... r switch to regulate signaling
@en
P2093
Bon-Kyung Koo
Eok-Soo Oh
Eva Mortier
James R Whiteford
John R Couchman
Pascale Zimmermann
P304
P356
10.1016/J.JMB.2005.09.087
P407
P577
2005-11-04T00:00:00Z