SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

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SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

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2017 nî lūn-bûn

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2017年の論文

@ja

2017年学术文章

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2017年学术文章

@zh

2017年学术文章

@zh-cn

2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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name

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

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SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

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label

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

@en

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

@nl

prefLabel

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

@en

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

@nl

P1476

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

@en

P2093

Dohyun Son

http://www.w3.org/2001/XMLSchema#string

Dong-Oh Yoon

http://www.w3.org/2001/XMLSchema#string

Dongyun Shin

http://www.w3.org/2001/XMLSchema#string

Hyun-Ju Park

http://www.w3.org/2001/XMLSchema#string

Jaesook Yun

http://www.w3.org/2001/XMLSchema#string

Jung Tae Han

http://www.w3.org/2001/XMLSchema#string

Xiaodi Zhao

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P2860

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist

Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

P304

1336-1340

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P31

scholarly article

P356

10.1021/ACSMEDCHEMLETT.7B00460

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2017-11-21T00:00:00Z

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P698

29259758

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P932

5733302

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