Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

about

Recent progress in developing selective inhibitors of protein methyltransferases.Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.

P2860

Q39405190-0B578F95-BF39-4E34-B7D0-1D5084B88FCF Q39423291-3B9581BA-EC10-49A0-B811-1E04B2F03CD6

P2860

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

Item

http://www.wikidata.org/entity/Q48273323

description

2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年学术文章

@wuu

2017年学术文章

@zh

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

@zh-hant

name

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@en

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@nl

type

Item

label

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@en

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@nl

prefLabel

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@en

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

@nl

P1476

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2

@en

P2093

Beau M Worley

http://www.w3.org/2001/XMLSchema#string

Fengling Li

http://www.w3.org/2001/XMLSchema#string

Jacob I Stuckey

http://www.w3.org/2001/XMLSchema#string

Jacqueline L Norris-Drouin

http://www.w3.org/2001/XMLSchema#string

Juliana The

http://www.w3.org/2001/XMLSchema#string

Kimberly D Barnash

http://www.w3.org/2001/XMLSchema#string

Masoud Vedadi

http://www.w3.org/2001/XMLSchema#string

Stephanie H Cholensky

http://www.w3.org/2001/XMLSchema#string

Stephen V Frye

http://www.w3.org/2001/XMLSchema#string

P2860

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

Targeting EZH2 in cancer

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.

Role of the polycomb protein EED in the propagation of repressive histone marks

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

The Polycomb complex PRC2 and its mark in life

The polycomb group protein EZH2 is involved in progression of prostate cancer

P304

161-172

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/ACSCOMBSCI.6B00174

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Peter J Brown

Cheryl Arrowsmith

Lindsey I James

P577

2017-02-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28165227

http://www.w3.org/2001/XMLSchema#string

P921

allosteric inhibitor

P932

5376495

http://www.w3.org/2001/XMLSchema#string

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

about

P2860

P2860

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P921

P932