The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression.
about
COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseMyeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent processCOP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulationCOP9-associated CSN5 regulates exosomal protein deubiquitination and sortingFunction of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradationDownregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stabilityAnalysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagyRole of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.JAB1/CSN5: a new player in cell cycle control and cancerBCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cellsIncreased cytoplasmic localization of p27(kip1) and its modulation of RhoA activity during progression of chronic myeloid leukemia.Gfer is a critical regulator of HSC proliferation.Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components.Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathwayThe organization of a CSN5-containing subcomplex of the COP9 signalosome.CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.RETRACTED: The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability.The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.p27 and leukemia: cell cycle and beyond.Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.Diversity of COP9 signalosome structures and functional consequences.Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells.Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosomeThe COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu.Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines.Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation.Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells.Novel aspects of COP9 signalosome functions revealed through analysis of hypomorphic csn mutants.Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells.Geminiviruses subvert ubiquitination by altering CSN-mediated derubylation of SCF E3 ligase complexes and inhibit jasmonate signaling in Arabidopsis thaliana.Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability.Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer.
P2860
Q24293399-1DA43170-4BE4-4894-B545-922CB4C3D995Q24301019-E3BA6198-DA97-4A0D-AB3A-0B70009C38EFQ24307876-5772FE48-DD4B-43B0-8587-1C35C33483E8Q24311222-3180E5B4-E4B9-49AA-8F1D-E3B9CAEABE5AQ24315611-12C7D523-80F4-4B21-953C-E6F6AEFF7A27Q31032769-AB1E11FB-D18D-4800-9A41-7A1DD967505FQ33311403-E61E1A10-9044-4167-B5B4-E52CA9107DBAQ33436063-2B3D7D18-509E-4CBA-BB62-5D13CF1C09B0Q33790284-665C4C2F-CB0E-4560-800D-C5E805E8588EQ34292695-5722D160-20CE-4422-AD86-B1C8CE6EE06AQ34551213-9A98478A-A91A-48AE-A256-0626D3DBF5FBQ34803110-9882F464-C1F2-4FB6-9CA7-E2CBDA940587Q35009496-77E5D643-C127-4F5B-BE23-A5FF378D679DQ35592116-FDFF3AF3-CCBA-426A-BC22-E9EE98476404Q36208477-35E84085-8613-4129-9CFC-25C401DAFC2BQ36407994-FCA700FB-EB01-4FEE-8740-2FD5C242E25BQ36451967-F2A94CB3-7B3C-4BD9-8BB8-30F6CF043A8AQ36524979-95C98570-A513-47D1-ADCA-4C443BD4AC17Q36667465-3511A65F-CD78-40DA-A6C9-A86940F69902Q37066433-E0B19E8B-6DF8-42AA-9DBA-7AA9C8310878Q38247694-D15D77FC-76E5-4406-A08F-811B4FBCE728Q38268491-C053A11C-50CD-4B7D-931F-88AA52A28E03Q38533869-F987149A-7979-4711-AE8A-1D3A09508156Q39249376-D0513717-BCA3-4E74-ACBE-29273EA5C284Q39470486-DA7BB599-943A-43D3-921B-70B3DA166B44Q39538233-7DA55052-747A-4F57-BE80-0E0661FC7EEFQ39816600-5AF699DC-8FB8-4516-AB94-E7879031D160Q39990453-30DC845B-4CE2-4BD6-9205-AA0202412F33Q40017171-57D72656-7C3C-4F80-9DF6-307B35BB28C6Q40222608-508D0476-01B7-4621-9F25-D3AD14D176A9Q40458488-AF0DE324-B91C-4036-B58C-113DB066EA7CQ40971143-AEEDF310-55DF-4318-BAA8-05A9143DE9AEQ42094573-60E29A94-0733-49D1-8D4A-20D1D558E84FQ42095359-21A77632-9D44-4E84-9047-EDD10516A98CQ43424639-B2AB2BD7-4BBC-42D7-AAA8-BA9A2EE36071Q44004792-2D731809-BD64-4064-9A2A-B82A0E9F8FA1Q49907436-0A1D962A-3114-4C08-9FF6-474C30D4EAA7Q52657204-203B221A-2932-47EB-87DF-BA7CF23EFC69
P2860
The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@en
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@nl
type
label
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@en
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@nl
prefLabel
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@en
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@nl
P2093
P1433
P1476
The Jab1/COP9 signalosome subc ...... itates cell-cycle progression.
@en
P2093
Eiji Tatsumi
Jun-ya Kato
Kiichiro Tomoda
Noriko Yoneda-Kato
Takayuki Takahashi
Yoshinobu Matsuo
P304
P356
10.1182/BLOOD-2004-04-1242
P407
P577
2004-09-07T00:00:00Z