Bcl-2 family proteins are essential for platelet survival.
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BH3 mimetics to improve cancer therapy; mechanisms and examplesCurrent challenges and novel treatment strategies in double hit lymphomasUnderstanding platelet generation from megakaryocytes: implications for in vitro-derived plateletsStructure-Guided Rescaffolding of Selective Antagonists of BCL-X LDiscovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based designPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Aspirin delimits platelet life span by proteasomal inhibitionChemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitorsNavitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease.Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer.Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human plateletsRegulatory role of proteasome in determination of platelet life spanABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia.Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.Adoptive transfer method to study platelet function in mouse models of disease.Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitorsThe Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.BCL-2 is dispensable for thrombopoiesis and platelet survivalNovel mechanisms of platelet clearance and thrombopoietin regulation.Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway.Platelet senescence and phosphatidylserine exposure.A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies.Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma developmentAgonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancerMammalian apoptosis in a parasitic worm.The essential role of evasion from cell death in cancer.Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.miR-326 targets antiapoptotic Bcl-xL and mediates apoptosis in human platelets.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancerBH3-only proteins in apoptosis at a glanceSelect Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma.The BCL-2 protein family, BH3-mimetics and cancer therapy.
P2860
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P2860
Bcl-2 family proteins are essential for platelet survival.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Bcl-2 family proteins are essential for platelet survival.
@en
Bcl-2 family proteins are essential for platelet survival.
@nl
type
label
Bcl-2 family proteins are essential for platelet survival.
@en
Bcl-2 family proteins are essential for platelet survival.
@nl
prefLabel
Bcl-2 family proteins are essential for platelet survival.
@en
Bcl-2 family proteins are essential for platelet survival.
@nl
P2093
P2860
P356
P1476
Bcl-2 family proteins are essential for platelet survival.
@en
P2093
Nasarre MC
Preusser LC
P2860
P2888
P304
P356
10.1038/SJ.CDD.4402081
P577
2007-01-05T00:00:00Z