about
A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BMps1 promotes rapid centromere accumulation of Aurora B.Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.Evolution and function of the mitotic checkpoint.Understanding force-generating microtubule systems through in vitro reconstitution.Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets.Dissecting the roles of human BUB1 in the spindle assembly checkpoint.Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.
P50
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P50
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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Mathijs Vleugel
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