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Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosingDiclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteersNUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicityContribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysisHighly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar rangeDNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinomaProton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.In vitro interaction of codeine and diclofenac.Dynamics and control of the central carbon metabolism in hepatoma cellsTranslational learning from clinical studies predicts drug pharmacokinetics across patient populations.Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency.Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique.Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate.Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity.Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes.Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone HydrolysisChemically induced mouse liver tumors are resistant to treatment with atorvastatin.MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.Chronopharmacology of intravenous and oral modified release verapamil.Enzymatically Modified Low-Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease.Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner.Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenesCellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).Patient education in a 14 month randomized trial fails to improve adherence in ulcerative colitis: Influence of demographic and clinical parameters on non-adherence.Comparative analysis of 3D culture methods on human HepG2 cells.Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor.Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison.Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transportersThe impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin.Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
P50
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P50
description
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հետազոտող
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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type
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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Ute Hofmann
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P106
P21
P31
P496
0000-0003-0823-9027