about
Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytesInsect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFNIntensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primatesProtection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming.Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapyHigh frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.Evaluation of a Salmonella Strain Lacking the Secondary Messenger C-di-GMP and RpoS as a Live Oral VaccineCaspase-dependent immunogenicity of doxorubicin-induced tumor cell death.CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitisIdentification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy.Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myelomaMitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.Direct effects of type I interferons on cells of the immune system.Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver.Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts.Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal.
P50
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P50
description
hulumtuese
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onderzoeker
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researcher
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հետազոտող
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name
Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
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Sandra Hervas-Stubbs
@nl
P106
P21
P31
P496
0000-0003-3391-1516